Leu-M1 immunoreactivity and phaeochromocytoma.

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Leu-M1 immunoreactivity and phaeochromocytoma.

The aim was to evaluate Leu-M1 immunoreactivity as a prognostic factor in phaeochromocytoma. Anti-Leu-M1 monoclonal antibodies were used to determine the Leu-M1 immunoreactivity in 17 histologically confirmed phaeochromocytomas from 15 patients, using an avidin-biotin technique. Ten patients had a sporadic phaeochromocytoma, and five had multiple endocrine neoplasia type 2A (MEN 2A). Malignancy...

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[Immunohistological grade of renal cell carcinoma employing anti Leu-M1 antibody and anti EMA antibody].

Attempting to establish more objective grading system of renal cell carcinoma, I studied 104 renal cell carcinoma tissue samples from 52 cases by immunohistochemical technique employing the anti-Leu M1 antibody and the anti-EMA antibody. These 52 cases could be classified into 4 groups according to the reactivity for Leu-M1 (L) and EMA (E), i.e., L+E-, L+E+, L-E+, and L-E-. Considering the expr...

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Malignant phaeochromocytoma and hypercalcaemia.

We describe a case of hypercalcaemia secondary to recurrent malignant phaeochromocytoma. Parathyroid-related protein (PTHrp 1-86) immunoreactivity was identified in plasma and PTHrp was identified by immunocytochemistry in tumour tissue.

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Phaeochromocytoma and hypercalcaemia.

Introduction Phaeochromocytoma may occasionally induce hypercalcaemia. Case reports of correction of hypercalcaemia by surgical removal of the phaeochromocytoma indicate the importance of humoral mechanisms (Swinton, Clerkin and Flint, 1972; Kukreja et al., 1973). Kukreja et al. (1973) noted a pre-operative elevation of serum immuno-reactive parathyroid hormone (i-PTH) implying that hypercalcae...

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Hypercalcaemia and phaeochromocytoma.

A patient with a phaeochromocytoma associated with hypercalcemia is described. The hypercalcaemia was corrected by removal of the phaeochromocytoma. Parathyroid hormone-like peptide was isolated from the tumour suggesting that ectopic parathyroid hormone production from the phaeochromocytoma was the explanation of the hypercalcaemia.

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1997

ISSN: 0021-9746

DOI: 10.1136/jcp.50.2.168